Antioxidant Effect of Roots and Rhizomes of Smilax Zeylanica L. an in Vivo Study
نویسندگان
چکیده
Aim of the study: To evaluate the antioxidant property of Smilax zeylanica L. using CCl4 hepatotoxicity in rats. Materials and methods: Hepatotoxicity was induced in Wistar albino rats by administration of CCl4 (0.5ml/kg/day p.o. for 7days). Methanol extract of S. zeylanica roots and rhizomes (SZRM) was administered to the experimental animals at doses 200,400 and 600 mg/kg/day, p.o. for 7 days. Antioxidant effect was assessed by the estimation of hepatic levels of SOD, catalase, peroxidase, reduced glutathione, total proteins and malondialdehyde. Results: In methanol extract-treated animals, the toxic effect of CCl4 was controlled by restoration of the levels of hepatic antioxidant enzymes as compared to the positive control and standard drug silymarin-treated groups. The methanol extract at different doses exhibited significant increase in SOD, peroxidase, glutathione and proteins. The level of malondialdehyde was also significantly reduced. Conclusion: The study revealed that the S. zeylanica possesses strong antioxidant property.
منابع مشابه
Screening of methanol extract of roots and rhizomes of Smilax zeylanica L for hepatoprotective effect against carbontetrachloride induced hepatic damage
Objective: To evaluate the hepatoprotective potential of methanol extract of roots and rhizomes of Smilax zeylanica L on carbontetrachloride (CCl4) induced hepatotoxicity in Wistar albino rats. Methods: Hepatotoxicity was induced in Wistar albino rats of either sex by administration of CCl4 0.5 ml/kg p.o. once a day for 7 days. The methanol extract of roots and rhizomes of Smilax zeylanica L we...
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